2,3-DISUBSTITUTED-5,6-DIHYDRO-IMIDAZO(2,1-B)THIAZOLE, ITS SALT AND THEIR PREPARATION

2,3-DISUBSTITUTED-5,6-DIHYDRO-IMIDAZO(2,1-B)THIAZOLE, ITS SALT AND THEIR PREPARATION

NEW MATERIAL:A compound of formulaI(R is substituted or unsubstituted phenyl, naphthalyl) and its salt. EXAMPLE:2-( 3,4-Dichlorophenylcarbamoyl )-3-methyl-5,6-dihydroimidazo[2,1-b]- thiazole hydrochloride. USE:Anti-inflammatory: it has 10-40 times lower acute toxicity than levamisol and a stronger a...

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Bibliographische Detailangaben
Hauptverfasser: CHIYOMARU ISAO, OONO HIROSHI, TAKAYANAGI HOUKOU, YASUMA KATSUO, NISHIO KAZUO, YAMAMOTO KAZUKO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:A compound of formulaI(R is substituted or unsubstituted phenyl, naphthalyl) and its salt. EXAMPLE:2-( 3,4-Dichlorophenylcarbamoyl )-3-methyl-5,6-dihydroimidazo[2,1-b]- thiazole hydrochloride. USE:Anti-inflammatory: it has 10-40 times lower acute toxicity than levamisol and a stronger activity of resisting carrageenin edema than levamisol. PREPARATION:Almost equal amounts of a compound of formula II and N,N- ethyleneurea are made to react to give the compound of formulaI. The reaction is effected in a solvent such as benzene or toluene at -5-100 deg.C, preferably 20- 80 deg.C for 1-6hr in high yield and purity.