2-(4-BENZYLOXYPHENYL)-3-ACETOXY-5-(2-DIMETHYLAMINOETHYL)- 2,3-DIHYDRO-1,5-BENZOTHIAZEPIN-4(5H)-ONE AND ITS PREPARATION

2-(4-BENZYLOXYPHENYL)-3-ACETOXY-5-(2-DIMETHYLAMINOETHYL)- 2,3-DIHYDRO-1,5-BENZOTHIAZEPIN-4(5H)-ONE AND ITS PREPARATION

NEW MATERIAL:2-( 4-Benzyloxyphenyl )-3-acetoxy-5-(2-dimethylaminoethyl)-2, 3- dihydro-1,5-benzothiazepin-4-(5H)-one of formulaI, an optically active substance or acid addition salt thereof. USE:Useful as a medicine having the coronary vasodilator action or action on the central nervous system. PROCE...

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Hauptverfasser: UNEDA TAKASHI, MAEDA SADAYUKI, TAKATANI MASAHIRO, SHINOO YASUTAKA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:2-( 4-Benzyloxyphenyl )-3-acetoxy-5-(2-dimethylaminoethyl)-2, 3- dihydro-1,5-benzothiazepin-4-(5H)-one of formulaI, an optically active substance or acid addition salt thereof. USE:Useful as a medicine having the coronary vasodilator action or action on the central nervous system. PROCESS:2-( 4-Benzyloxyphenyl )-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4(5H)- one of formula II is reacted with a dimethylaminoethyl halide to give 2-(4-benzyloxyphenyl )-3-hydroxy-5-( 2-dimethylaminoethyl)-2, 3-dihydro-1, 5-benzothiazepin-4(5H)-one of formula III, which is then acetylated to afford the compound of formulaI.