ALPHAAAMINOMETHYLL55HYDOXYY 22PYRIDINEMETHANOLS

ALPHAAAMINOMETHYLL55HYDOXYY 22PYRIDINEMETHANOLS

alpha -Aminomethyl-5-hydroxy-2-pyridinemethanols having beta -adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and...

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Bibliographische Detailangaben
Hauptverfasser: CHIMOSHII YUUUUEN JIEN, KAARU KAIZAA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:alpha -Aminomethyl-5-hydroxy-2-pyridinemethanols having beta -adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and finally catalytic hydrogenation to remove benzyl protective groups.