NEW CYCLOALKYL DERIVATIVE AS BONE ABSORPTION INHIBITOR AND VITRONECTIN RECEPTOR ANTAGONIST

PROBLEM TO BE SOLVED: To obtain the subject new compound inhibiting the bone absorption of osteoclast and useful for bone diseases such as osteoporosis and hypercalcemia. SOLUTION: A compound of the formula: R -Y-A-B-D-E-F-G R is a (substituted) four to ten-membered ring, etc.; A is CO2 , etc.; B is a single direct bond, etc.; D, F are each O, etc.; E is a (substituted) aromatic ring system; G is a group of formula I [R is a 10-18C cycloalkyl, etc.; R is H, etc.; R is pyrazolyl, etc.; (q) is 0, 1]; Y is NR (R is H, etc.}. For example, a compound of formula II. The objective compound of the formula wherein F is C(O)NR is obtained e.g. by condensing a compound of the formula: R -Y-A-B-D-E-M (M is hydroxycarbonyl, etc.), with a compound of the formula: HNR -G. When orally administered as a medicine, the objective compound is preferably administered at a daily dose of 0.01-50 mg/kg.