BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT OF BONE AND CARTILAGE
PROBLEM TO BE SOLVED: To provide the subject novel compound that is useful as an active ingredient for pharmaceutical composition that is useful for prevention and treatment of diseases of bone and cartilage. SOLUTION: This novel compound is represented by formula I [R and R are each H, a 1-15C (sub...
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| creator | SAKAI KUNIKAZU SATO SUKENORI |
| description | PROBLEM TO BE SOLVED: To provide the subject novel compound that is useful as an active ingredient for pharmaceutical composition that is useful for prevention and treatment of diseases of bone and cartilage. SOLUTION: This novel compound is represented by formula I [R and R are each H, a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) arly; R is a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) aryl], typically 1,3-dibenzyl-5-(3-methyl-1-oxobutyl) barbituric acid. The compound of formula I is prepared, for example, by condensation reaction of a barbituric acid derivative of formula II with an acylating agent of formula III. The daily dose of the compound of formula I is 0.01-2 g (about 0.15-30 mg/kg/day). |
| format | Patent |
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SOLUTION: This novel compound is represented by formula I [R and R are each H, a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) arly; R is a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) aryl], typically 1,3-dibenzyl-5-(3-methyl-1-oxobutyl) barbituric acid. The compound of formula I is prepared, for example, by condensation reaction of a barbituric acid derivative of formula II with an acylating agent of formula III. The daily dose of the compound of formula I is 0.01-2 g (about 0.15-30 mg/kg/day).</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991012&DB=EPODOC&CC=JP&NR=H11279157A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991012&DB=EPODOC&CC=JP&NR=H11279157A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SAKAI KUNIKAZU</creatorcontrib><creatorcontrib>SATO SUKENORI</creatorcontrib><title>BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT OF BONE AND CARTILAGE</title><description>PROBLEM TO BE SOLVED: To provide the subject novel compound that is useful as an active ingredient for pharmaceutical composition that is useful for prevention and treatment of diseases of bone and cartilage. SOLUTION: This novel compound is represented by formula I [R and R are each H, a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) arly; R is a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) aryl], typically 1,3-dibenzyl-5-(3-methyl-1-oxobutyl) barbituric acid. The compound of formula I is prepared, for example, by condensation reaction of a barbituric acid derivative of formula II with an acylating agent of formula III. The daily dose of the compound of formula I is 0.01-2 g (about 0.15-30 mg/kg/day).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh1cgxy8gwJDfJ0VnB09nRRcHEN8gxzDPEMc1Vw9HNRCAhyDXP1g3NDPFyDHANcQ0NAyt2BEgr-bgpO_n4QWWfHoBBPH6A4DwNrWmJOcSovlOZmUHRzDXH20E0tyI9PLS5ITE7NSy2J9wrwMDQ0Mrc0NDV3NCZGDQA3ozA-</recordid><startdate>19991012</startdate><enddate>19991012</enddate><creator>SAKAI KUNIKAZU</creator><creator>SATO SUKENORI</creator><scope>EVB</scope></search><sort><creationdate>19991012</creationdate><title>BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT OF BONE AND CARTILAGE</title><author>SAKAI KUNIKAZU ; SATO SUKENORI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH11279157A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SAKAI KUNIKAZU</creatorcontrib><creatorcontrib>SATO SUKENORI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SAKAI KUNIKAZU</au><au>SATO SUKENORI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT OF BONE AND CARTILAGE</title><date>1999-10-12</date><risdate>1999</risdate><abstract>PROBLEM TO BE SOLVED: To provide the subject novel compound that is useful as an active ingredient for pharmaceutical composition that is useful for prevention and treatment of diseases of bone and cartilage. SOLUTION: This novel compound is represented by formula I [R and R are each H, a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) arly; R is a 1-15C (substituted) alkyl or alkenyl; a (substituted) arylmethyl or a (substituted) aryl], typically 1,3-dibenzyl-5-(3-methyl-1-oxobutyl) barbituric acid. The compound of formula I is prepared, for example, by condensation reaction of a barbituric acid derivative of formula II with an acylating agent of formula III. The daily dose of the compound of formula I is 0.01-2 g (about 0.15-30 mg/kg/day).</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT OF BONE AND CARTILAGE |
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