SYNTHESIS OF 6-(18F)FLUORO-L-DOPA

PROBLEM TO BE SOLVED: To obtain the subject compound useful as a labeling agent, etc., for diagnosing the cerebral dopamine synthetic ability by converting 4-[18 F]fluorocatechol into a 6-[18F]fluoro-L-DOPA according to a reaction with a β-tyrosinase. SOLUTION: The 4-[18F]fluofocatechol represented...

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Bibliographische Detailangaben
Hauptverfasser:	YADA TAKAKO, KANEKO SHOJI, KOMURA KEIGO, ISHIWATARI KIICHI, FURUYA YUJI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain the subject compound useful as a labeling agent, etc., for diagnosing the cerebral dopamine synthetic ability by converting 4-[18 F]fluorocatechol into a 6-[18F]fluoro-L-DOPA according to a reaction with a β-tyrosinase. SOLUTION: The 4-[18F]fluofocatechol represented by formula I is converted into 6-[18F]fluoro-L-DOPA represented by formula II according to an enzymic reaction with an enzyme such as a β-tyrosinase obtained by a recombinant Escherichia coli in which a β-tyrosinase gene of Citrobacter intermedius is transferred to thereby suppress the production of an isomer and afford the objective 6-[18F]fluoro-L-DOPA in a high yield. The resultant compound is useful as a labeling agent, etc., for diagnosing the cerebral dopamine synthetic ability by positron emission tomography (PET), etc.