PRODUCTION OF FORMYLIMIDAZOLE

PROBLEM TO BE SOLVED: To economically obtain without any disadvantage a formylimidazole useful as an important intermediate for producing diuretics or the like, by performing a catalytic oxidation in the presence of a peroxide. SOLUTION: This formylimidazole of formula I or formula II [R is H or a (...

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Hauptverfasser:	HEVELING JOSEF DR, WELLIG ALAIN
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To economically obtain without any disadvantage a formylimidazole useful as an important intermediate for producing diuretics or the like, by performing a catalytic oxidation in the presence of a peroxide. SOLUTION: This formylimidazole of formula I or formula II [R is H or a (substituted) alkyl; R is H, a (substituted) alkyl, aryl or the like; R is H or a (substituted) alkyl] is obtained by catalytic oxidation of a hydroxymethylimidazole of formula III or formula IV in the presence of a noble metal catalyst (pre. platinum/bismuth catalyst or platinum/lead catalyst) and also in the presence of a peroxide (pref. hydrogen peroxide) pref. at 20-120 deg.C; wherein it is preferable that the catalytic oxidation is carried out in the presence of water, a polar solvent miscible with water, nonpolar solvent immiscible with water, or a mixture thereof, in an alkaline medium incorporated with an alkali metal hydroxide or the like.