NEW AMINO ACID DERIVATIVE

PROBLEM TO BE SOLVED: To obtain the subject new compound useful as a chemokine receptor antagonist capable of inhibiting diseases caused by the chemokine such as interleukin 8 or MIP-1 α. SOLUTION: This compound is represented by the formula; R -X -ph-X -A-Y- R [A is D or L-Arg, Lys or the like; X i...

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Bibliographische Detailangaben
Hauptverfasser:	YAMAZAKI TORU, SUZUKI SHIGERU, EDAMATSU TAKEO, YANAKA MIKIRO, DEWA TOSHIKAZU, TAKEMURA YOSHIYUKI, INOGUCHI EIJI, MARUOKA HIROSHI, HIROSE KUNITAKA, HAKOZAKI MITSUNORI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain the subject new compound useful as a chemokine receptor antagonist capable of inhibiting diseases caused by the chemokine such as interleukin 8 or MIP-1 α. SOLUTION: This compound is represented by the formula; R -X -ph-X -A-Y- R [A is D or L-Arg, Lys or the like; X is NH, O or the like; X is absent, SO2 or the like; Y is S, O or the like; R and R are each a 12-30C straight-chain alkyl, cholesteryl or the like], e.g. 2-(isopropylcarbamoyl)-benzoyl-L-arginine-n- hexadecylamide. The compound is obtained by condensing, e.g. an N-terminal protected amino acid with a compound represented by the formula; R -Y-H, then removing the N-terminal protecting group, condensing the resultant compound represented by the formula; A'-Y-R (A' is an amino acid having the protected side chain) with a compound represented by the formula; R X -ph-X -Z (Z is a halogen or hydroxyl group) and prepared by condensing a compound represented by the formula; R -X -Z with a compound represented by the formula; X -ph-X -OR (R is a protecting group) and subsequently deprotecting the obtained compound and further removing the side chain protecting group of the amino acid.