NEW CARBOXYLIC ACID DERIVATIVE AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain a new compound useful as a medicine or the like, especially a manufacturing intermediate for an antiplatelet drug. SOLUTION: This new compound is a compound of formula I (R is H or a lower alkyl), e.g. [6-(benzyloxycarboxamide)-2H-1-benzopyran-3-yl]acetate. The compou...

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Bibliographische Detailangaben
Hauptverfasser:	OOTSUKA KENGO, SHIMAZAKI TOSHIYUKI, AWANO HIROICHI, OKUMURA KUNIO, YAMASHITA HIROYUKI
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain a new compound useful as a medicine or the like, especially a manufacturing intermediate for an antiplatelet drug. SOLUTION: This new compound is a compound of formula I (R is H or a lower alkyl), e.g. [6-(benzyloxycarboxamide)-2H-1-benzopyran-3-yl]acetate. The compound of the formula I is obtained by carrying out a dehydration reaction of (A) γ-hydroxycarboxylic acid ester derivative of formula II (R is a lower alkyl), e.g. methyl[6(benzyloxycarboxamide)-4-hydroxy-3,4-dihydro-2H-1- benzopyran-3-yl]acetate) with (B) an acidic ion-exchange resin preferably of a strongly acidic ion-exchange resin of a sulfonic acid type of 1-200 wt.% based on the component A, as a catalyst in the presence of (C) molecular sheaves, preferably powdery molecular sheaves 3A, of about 10-200 wt.% based on the component A at 20-200 deg.C.