INSPECTION OF CHRONIC REJECTION REACTION AFTER ORGAN TRANSPLANTATION AND MEASUREMENT OF COMPONENTS IN URINE

INSPECTION OF CHRONIC REJECTION REACTION AFTER ORGAN TRANSPLANTATION AND MEASUREMENT OF COMPONENTS IN URINE

PROBLEM TO BE SOLVED: To simply detect the rejection reaction after organ transplantation by detecting the matrix metalloprotease 2 or its precursor in the body fluid to early detect the chronic rejection reaction after transplantation of an organ such as kidney. SOLUTION: The concentration of matri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TANABE TOSHIO, SAIGA HIROSHI, NEMOTO KYUICHI, ISODA ATSUKO, TAKAGI HISAKO
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To simply detect the rejection reaction after organ transplantation by detecting the matrix metalloprotease 2 or its precursor in the body fluid to early detect the chronic rejection reaction after transplantation of an organ such as kidney. SOLUTION: The concentration of matrix metalloprotease(MMP)-2 or its precursor in human body fluid, for example, human urea or blood, is determined by the enzyme immunoassay, in addition the creatinine concentration is determined to correct the MMP-2 value with the creatinine concentration to give an index. The cut-off value for judging whether chronic renal transplantation rejection reaction has occurred or not is set between 0.0-20.0μg/g. creatinine and the cut-off value is set to 0.5-10.0μg/g. creatinine whereby the early detection of chronic post-operative rejection reaction becomes possible.