CIRCULATORY ORGAN MEDICINE CONTAINING 3-PYRIDYLAMINO COMPOUND OR ITS SALT

PROBLEM TO BE SOLVED: To obtain a new compound having a strong serotonin-2 receptorantagonizing action and useful for treating and preventing circulatory organ diseases. SOLUTION: This new compound is expressed by formula I [A is one of a group consisting of CO and S02; B is a single bond, CHOH, carbonyl; D is methine, N; Q is methine, N; R1 is H, a halogen, a lower alkoxy, a (substituted) amino, etc.; R2 is H, a halogen, a lower alkoxy; R is H, a halogen; (n) is 2, 3], e.g. 4-amino-N-[2-(4-benzoyl-1-piperidinyl) ethyl]-N-(3-pyridyl)benzamide. The compound of formula I is obtained by reacting a compound of formula II (X is OH, a halogen) with a compound of formula III. The compound of formula I has a serotonin vasopressor-inhibiting action and an infarction- inhibiting action in a carrageenin-induced peripheral circulatory disorder model, and is useful for ischemic heart diseases, cerebrovascular diseases, peripheral circulatory disorders, diabetic complications, etc.