DIMETHYL-(3-ARYL-BUTO-3-ENYL)-AMINO COMPOUND AS PHARMACEUTICALLY ACTIVE SUBSTANCE

PROBLEM TO BE SOLVED: To obtain the subject new compound having excellent analgesic action, free from adverse effects of sickness, vomiting, etc., not exhibiting adverse effects which opioid have and useful as a therapeutic agent for strong pain. SOLUTION: An antipode or a racemic modification of a compound (salt) represented by formula I [R is a 1-5C alkyl; R is H or R or R and R together form (CH2 )2-4 , etc.; R is H or R ; R and R are each H, OH, a 1-4C alkyl(oxy), etc.; R is R or CHF2 ; in R to R , two groups among R to R are each H or R and R together form a group of the formula CH=C(R )-O (R is H or a 1-4C alkyl), a group of the formula CH=C(R )-S, etc.], e.g. (Z)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-pento-3-enyl]-dimethylamine hydrochloride. The compound of formula I is obtained by reacting a compound of formula II with a compound of formula III (Z is MgCl, MgBr, MgI or Li) to afford a compound of formula IV and dehydrating the compond of formula IV.