GENE OF PAPILLOMA VIRUS PROTEIN OF HAMSTER ORAL CAVITY

PROBLEM TO BE SOLVED: To obtain the subject new gene useful for diagnosing an infectious disease with a papilloma virus related to a cancer, treatment, screening for anticancer agents, etc., coding a papilloma virus protein (E1) of hamster oral cavity having a specific amino acid sequence. SOLUTION:...

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Hauptverfasser: MORIYAMA MASAMI, SAITOU MAKIKO, IWASAKI TAKUYA
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain the subject new gene useful for diagnosing an infectious disease with a papilloma virus related to a cancer, treatment, screening for anticancer agents, etc., coding a papilloma virus protein (E1) of hamster oral cavity having a specific amino acid sequence. SOLUTION: This new gene codes a papilloma virus protein (E1) of hamster oral cavity having a specific amino acid sequence of the formula and is useful for diagnosing an infectious disease with a papilloma virus related to a cancer, screening for anticancer agents, anti-sense treatment, vaccine treatment, preparation of animal model animal, etc. The new gene is obtained by extracting a DNA from a precancerous lesion tissue induced in a hamster oral cavity mucosa by 9,10-dimethyl-1,2-benzanthracene (DMBA), treating the DNA with a restricted enzyme, separating the treated DNA by electrophoresis, transferring the separated DNA to a nitrocellulose membrane and screening the DNA by a human papilloma virus DNA fragment as a probe.