REACTIVE TRICALCIUM PHOSPHATE COMPOSITION AND USE

PROBLEM TO BE SOLVED: To obtain a reactive tricalcium phosphate composition stable at room temperatures and giving α-tricalcium phosphate products in a pure phase by including a physiologically acceptable lubricant and a calcium phosphate cement composition comprising reactive α-tricalcium phosphate...

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Hauptverfasser: ISON IRA C, BARR BRYAN M, FULMER MARK, CONSTANTZ BRENT R
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain a reactive tricalcium phosphate composition stable at room temperatures and giving α-tricalcium phosphate products in a pure phase by including a physiologically acceptable lubricant and a calcium phosphate cement composition comprising reactive α-tricalcium phosphate, a calcium source and a partially neutralized phosphoric acid source. SOLUTION: Reactive α-tricalcium phosphate is produced by reacting a stoichiometric mixture of CaHPO4 and CaCO3 with each other in an aqueous reaction solvent at a pressure of 0.35-2.1 kg/cm , heating the obtained product having a Ca : phosphate group ratio of 1.5:1 at 1200-1700 deg.C for 1-8 hr and subsequently quenching the product. >=20 wt.% of the obtained reactive α-tricalcium phosphate is compounded with 0.1-10 wt.% of at least one kind of an additional calcium source (e.g. calcium hydroxide) and 1.0-40 wt.% of a partially neutralized phosphoric acid source to obtain a calcium phosphate cement composition. The composition is compounded with a physiologically acceptable lubricant (e.g. water) to provide the objective reactive tricalcium phosphate composition.