NEW PRODUCTION OF AZITHROMYCIN

PROBLEM TO BE SOLVED: To provide a method for producing azithromycin, enabling to obtain the highly pure azithromycin in a high yield. SOLUTION: This method for producing azithromycin comprises producing the azithromycin from a proper iminoether used as a precursor. Therein, the reduction reaction a...

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Hauptverfasser:	DE MOURO VAZ AZEVEDO MENDES ZITA MARIA, HEGGIE WILLIAM DR
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for producing azithromycin, enabling to obtain the highly pure azithromycin in a high yield. SOLUTION: This method for producing azithromycin comprises producing the azithromycin from a proper iminoether used as a precursor. Therein, the reduction reaction and the reductive methylation reaction are continuously carried out with hydrogen in the presence of a formaldehyde or its supply source and a noble metal catalyst, and both the reactions are performed in the same reaction vessel.