THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES
PROBLEM TO BE SOLVED: To obtain the subject compound, capable of inhibiting the separation of TNF-α which causes the inflammation, and the antiger induced synthesis of the interleukin 2, and used as a thalidomide-like compound without a toxicological danger. SOLUTION: This compound is a substituted...
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| creator | WNENDT STEPHAN DR ZIMMER OSWALD DR EGER KURT WINTER WERNER ZWINGENBERGER KAI TEUBERT UWE |
| description | PROBLEM TO BE SOLVED: To obtain the subject compound, capable of inhibiting the separation of TNF-α which causes the inflammation, and the antiger induced synthesis of the interleukin 2, and used as a thalidomide-like compound without a toxicological danger. SOLUTION: This compound is a substituted piperidine-2,6-dione of formula I [Z is C(R R )-CH2 or C(R )=CH; R is phthalimide, etc.; R is H or a 1-6C alkyl; R is H, a 1-6C alkyl or a (hetero)aromatic ring; R is a 1-6C alkyl or a (hetero)aromatic ring], for instance, 2-(5-methyl-2,6-dioxo-piperidin-3-yl)-1,3- dihydro-2H-isoindole-1,3-dione. The compound of formula I is obtained, for instance, by condensing a substituted glutamic acid with a phthalic anhydride, carrying out cyclization of the product to provide an anhydride, and converting the anhydride into an imide. |
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SOLUTION: This compound is a substituted piperidine-2,6-dione of formula I [Z is C(R R )-CH2 or C(R )=CH; R is phthalimide, etc.; R is H or a 1-6C alkyl; R is H, a 1-6C alkyl or a (hetero)aromatic ring; R is a 1-6C alkyl or a (hetero)aromatic ring], for instance, 2-(5-methyl-2,6-dioxo-piperidin-3-yl)-1,3- dihydro-2H-isoindole-1,3-dione. The compound of formula I is obtained, for instance, by condensing a substituted glutamic acid with a phthalic anhydride, carrying out cyclization of the product to provide an anhydride, and converting the anhydride into an imide.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19981202&DB=EPODOC&CC=JP&NR=H10316675A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19981202&DB=EPODOC&CC=JP&NR=H10316675A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WNENDT STEPHAN DR</creatorcontrib><creatorcontrib>ZIMMER OSWALD DR</creatorcontrib><creatorcontrib>EGER KURT</creatorcontrib><creatorcontrib>WINTER WERNER</creatorcontrib><creatorcontrib>ZWINGENBERGER KAI</creatorcontrib><creatorcontrib>TEUBERT UWE</creatorcontrib><title>THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES</title><description>PROBLEM TO BE SOLVED: To obtain the subject compound, capable of inhibiting the separation of TNF-α which causes the inflammation, and the antiger induced synthesis of the interleukin 2, and used as a thalidomide-like compound without a toxicological danger. 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The compound of formula I is obtained, for instance, by condensing a substituted glutamic acid with a phthalic anhydride, carrying out cyclization of the product to provide an anhydride, and converting the anhydride into an imide.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAK8XD08XTx9_V0cdX18fR2VXD29w3wD_VzATOCPIM9_dwVAjwDXIM8XTz9XHWNdMx0XTz9_VyDeRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvFeAh6GBsaGZmbmpozExagC41iks</recordid><startdate>19981202</startdate><enddate>19981202</enddate><creator>WNENDT STEPHAN DR</creator><creator>ZIMMER OSWALD DR</creator><creator>EGER KURT</creator><creator>WINTER WERNER</creator><creator>ZWINGENBERGER KAI</creator><creator>TEUBERT UWE</creator><scope>EVB</scope></search><sort><creationdate>19981202</creationdate><title>THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES</title><author>WNENDT STEPHAN DR ; ZIMMER OSWALD DR ; EGER KURT ; WINTER WERNER ; ZWINGENBERGER KAI ; TEUBERT UWE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH10316675A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WNENDT STEPHAN DR</creatorcontrib><creatorcontrib>ZIMMER OSWALD DR</creatorcontrib><creatorcontrib>EGER KURT</creatorcontrib><creatorcontrib>WINTER WERNER</creatorcontrib><creatorcontrib>ZWINGENBERGER KAI</creatorcontrib><creatorcontrib>TEUBERT UWE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WNENDT STEPHAN DR</au><au>ZIMMER OSWALD DR</au><au>EGER KURT</au><au>WINTER WERNER</au><au>ZWINGENBERGER KAI</au><au>TEUBERT UWE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES</title><date>1998-12-02</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain the subject compound, capable of inhibiting the separation of TNF-α which causes the inflammation, and the antiger induced synthesis of the interleukin 2, and used as a thalidomide-like compound without a toxicological danger. SOLUTION: This compound is a substituted piperidine-2,6-dione of formula I [Z is C(R R )-CH2 or C(R )=CH; R is phthalimide, etc.; R is H or a 1-6C alkyl; R is H, a 1-6C alkyl or a (hetero)aromatic ring; R is a 1-6C alkyl or a (hetero)aromatic ring], for instance, 2-(5-methyl-2,6-dioxo-piperidin-3-yl)-1,3- dihydro-2H-isoindole-1,3-dione. The compound of formula I is obtained, for instance, by condensing a substituted glutamic acid with a phthalic anhydride, carrying out cyclization of the product to provide an anhydride, and converting the anhydride into an imide.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES |
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