THALIDOMIDE-LIKE COMPOUND COMPRISING PIPERIDINE-2,6-DIONES

PROBLEM TO BE SOLVED: To obtain the subject compound, capable of inhibiting the separation of TNF-α which causes the inflammation, and the antiger induced synthesis of the interleukin 2, and used as a thalidomide-like compound without a toxicological danger. SOLUTION: This compound is a substituted piperidine-2,6-dione of formula I [Z is C(R R )-CH2 or C(R )=CH; R is phthalimide, etc.; R is H or a 1-6C alkyl; R is H, a 1-6C alkyl or a (hetero)aromatic ring; R is a 1-6C alkyl or a (hetero)aromatic ring], for instance, 2-(5-methyl-2,6-dioxo-piperidin-3-yl)-1,3- dihydro-2H-isoindole-1,3-dione. The compound of formula I is obtained, for instance, by condensing a substituted glutamic acid with a phthalic anhydride, carrying out cyclization of the product to provide an anhydride, and converting the anhydride into an imide.