ACID ADDUCT SALT OF OPTICALLY ACTIVE PIPERDINE DERIVATIVE

ACID ADDUCT SALT OF OPTICALLY ACTIVE PIPERDINE DERIVATIVE

PROBLEM TO BE SOLVED: To obtain the subject compound having an excellent stability suitable as a medicine by forming a salt of a specific derivative with benzene sulfonic acid, etc. SOLUTION: This acid adduct salt of an optically active piperidine derivative is an objective salt expressed by the for...

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Bibliographische Detailangaben
Hauptverfasser: FUJIWARA HIROSHI, KITA JUNICHIRO, TAKAMURA SHINJI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain the subject compound having an excellent stability suitable as a medicine by forming a salt of a specific derivative with benzene sulfonic acid, etc. SOLUTION: This acid adduct salt of an optically active piperidine derivative is an objective salt expressed by the formula and having an absoluyte configuration of (S) compound, preferably (S)-4- 4-[(4-chlorophenyl)(2-pyridyl) methoxy]piperidino}butanoic acid.benzene sulfonic acid salt. Further, in order to obtain the above salt, it is preferable to form the salt by using 0.8-2.5 fold mol of benzene sulfonic acid or benzoic acid based on 1mol of (S)-piperidine derivative expressed by the formula in a solvent such as ethanol a 5-50 deg.C reaction temperature.