ANTITUMOR MEDICINE

PROBLEM TO BE SOLVED: To obtain an antitumor medicine containing a specific pyrimidine derivative or its salt as an active ingredient, having an excellent antitumor activity and low in toxicity. SOLUTION: This antitumor medicine contains at least one of a pyrimidine derivative of formula I [R is H,...

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Bibliographische Detailangaben
Hauptverfasser: FUJI KAORU, BONSHIHARA YASUKO, NOIDE MANABU, NISHIDE KIYOJI, IWAKURA BUNGETSU, OTA YOICHIRO, KAWANISHI KENJI, KUKI MASAKATSU
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Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain an antitumor medicine containing a specific pyrimidine derivative or its salt as an active ingredient, having an excellent antitumor activity and low in toxicity. SOLUTION: This antitumor medicine contains at least one of a pyrimidine derivative of formula I [R is H, an alkyl, a halogen, OH, an alkoxy, etc., R2 is H, NH2 , NHCOCH3 ; R3 is a group of formula II (R5 is H, an alkyl), a group of formula III (R6 , R7 are each an alkyl; R8 is H, OH, a hydroxyalkyl, etc.), etc.] and its pharmacologically acceptable salt as an active ingredient. The compound of fomrula I is especially preferably 2,3-diamno-4-[[[1- hydroxymethyl-3-(2-phenylenthyl)-1-cyclobutyl]methyl]amino]pyrimidine. The compound of formula I is preferably contained in an amount of 0.01-90wt.% based on the whole amount of the medicine, and is administered to a therapeutic patient at a daily dose of 0.1-1,000mg/kg.