ANTIHYPERTENSIVE MEDICINE CONTAINING SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE
PROBLEM TO BE SOLVED: To obtain an antihypertensive medicine effective for treating and preventing hypertensive patients by including a specific substituted thiazolidinedione derivative. SOLUTION: This antihypertensive medicine contains a compound of the formula [A is a (substituted) aromatic hetero...
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| description | PROBLEM TO BE SOLVED: To obtain an antihypertensive medicine effective for treating and preventing hypertensive patients by including a specific substituted thiazolidinedione derivative. SOLUTION: This antihypertensive medicine contains a compound of the formula [A is a (substituted) aromatic heterocyclic group; R is H, an alkyl, an acyl, an aralkyl, etc.; R , R are each H, or R , R are bound to each other to form a bond; A is a benzene ring having totally five or less substituents; (n) is 2-6], its tautomer, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate, e.g. 5-(4-[2-(N-methyl-N-(2-benzothiazolyl) amino]ethoxy]benzyl)-2,4-thiazolidinedione. The compound of the formula is obtained by subjecting 5-(4-[2-N-methyl-N-(2-benzothiazolyl) amino]ethoxyl]benzylidene)-2,4-thiazolidinedione to a hydrogenation reaction in the presence of palladium in 1,4-dioxane, etc. |
| format | Patent |
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SOLUTION: This antihypertensive medicine contains a compound of the formula [A is a (substituted) aromatic heterocyclic group; R is H, an alkyl, an acyl, an aralkyl, etc.; R , R are each H, or R , R are bound to each other to form a bond; A is a benzene ring having totally five or less substituents; (n) is 2-6], its tautomer, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate, e.g. 5-(4-[2-(N-methyl-N-(2-benzothiazolyl) amino]ethoxy]benzyl)-2,4-thiazolidinedione. The compound of the formula is obtained by subjecting 5-(4-[2-N-methyl-N-(2-benzothiazolyl) amino]ethoxyl]benzylidene)-2,4-thiazolidinedione to a hydrogenation reaction in the presence of palladium in 1,4-dioxane, etc.</description><edition>6</edition><language>eng</language><subject>APPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES ; CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SEPARATION ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TRANSPORTING</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980728&DB=EPODOC&CC=JP&NR=H10194971A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980728&DB=EPODOC&CC=JP&NR=H10194971A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HINDLEY RICHARD M</creatorcontrib><title>ANTIHYPERTENSIVE MEDICINE CONTAINING SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE</title><description>PROBLEM TO BE SOLVED: To obtain an antihypertensive medicine effective for treating and preventing hypertensive patients by including a specific substituted thiazolidinedione derivative. SOLUTION: This antihypertensive medicine contains a compound of the formula [A is a (substituted) aromatic heterocyclic group; R is H, an alkyl, an acyl, an aralkyl, etc.; R , R are each H, or R , R are bound to each other to form a bond; A is a benzene ring having totally five or less substituents; (n) is 2-6], its tautomer, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate, e.g. 5-(4-[2-(N-methyl-N-(2-benzothiazolyl) amino]ethoxy]benzyl)-2,4-thiazolidinedione. The compound of the formula is obtained by subjecting 5-(4-[2-N-methyl-N-(2-benzothiazolyl) amino]ethoxyl]benzylidene)-2,4-thiazolidinedione to a hydrogenation reaction in the presence of palladium in 1,4-dioxane, etc.</description><subject>APPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES</subject><subject>CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SEPARATION</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB19Avx9IgMcA0KcfUL9gxzVfB1dfF09vRzVXD29wtx9PTz9HNXCA51Cg7xDAkNcXVRCPHwdIzy9_F0Aapx8fQHKnRxDfIMcwwBauZhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfFeAR6GBoaWJpbmho7GxKgBAF_IL1Y</recordid><startdate>19980728</startdate><enddate>19980728</enddate><creator>HINDLEY RICHARD M</creator><scope>EVB</scope></search><sort><creationdate>19980728</creationdate><title>ANTIHYPERTENSIVE MEDICINE CONTAINING SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE</title><author>HINDLEY RICHARD M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH10194971A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>APPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES</topic><topic>CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SEPARATION</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>HINDLEY RICHARD M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HINDLEY RICHARD M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIHYPERTENSIVE MEDICINE CONTAINING SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE</title><date>1998-07-28</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain an antihypertensive medicine effective for treating and preventing hypertensive patients by including a specific substituted thiazolidinedione derivative. SOLUTION: This antihypertensive medicine contains a compound of the formula [A is a (substituted) aromatic heterocyclic group; R is H, an alkyl, an acyl, an aralkyl, etc.; R , R are each H, or R , R are bound to each other to form a bond; A is a benzene ring having totally five or less substituents; (n) is 2-6], its tautomer, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate, e.g. 5-(4-[2-(N-methyl-N-(2-benzothiazolyl) amino]ethoxy]benzyl)-2,4-thiazolidinedione. The compound of the formula is obtained by subjecting 5-(4-[2-N-methyl-N-(2-benzothiazolyl) amino]ethoxyl]benzylidene)-2,4-thiazolidinedione to a hydrogenation reaction in the presence of palladium in 1,4-dioxane, etc.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | APPARATUS USING FREE VORTEX FLOW, e.g. CYCLONES CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING |
| title | ANTIHYPERTENSIVE MEDICINE CONTAINING SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVE |
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