TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME

PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-rem...

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Hauptverfasser:	SHIBOUTA YUMIKO, KAWAMOTO TETSUJI, TAKATANI MUNEO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	SHIBOUTA YUMIKO KAWAMOTO TETSUJI TAKATANI MUNEO
description	PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-remedying effect, lipid reducing effect, etc. SOLUTION: This new tricyclic compound (salt) is shown by formula I [A- ring may have substituent(s); B-ring may be replaced by one oxo group; X is an active bond or (substituted) divalent hydrocarbon group; Y is a (substituted) nitrogen-contg. heterocycle; R is an electron-attracting group], e.g. 1,2- dihydro-1-(1-trifluoromethanesulfonylpiperidin-4-ylmethyl)-1,4,7b- triazacyclopento[cd]inden-2-one. The compound of formula I is obtained by reaction between a compound of formula II and a compound of formula III (E is a leaving group).
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The compound of formula I is obtained by reaction between a compound of formula II and a compound of formula III (E is a leaving group).</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980707&DB=EPODOC&CC=JP&NR=H10182644A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980707&DB=EPODOC&CC=JP&NR=H10182644A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHIBOUTA YUMIKO</creatorcontrib><creatorcontrib>KAWAMOTO TETSUJI</creatorcontrib><creatorcontrib>TAKATANI MUNEO</creatorcontrib><title>TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME</title><description>PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-remedying effect, lipid reducing effect, etc. SOLUTION: This new tricyclic compound (salt) is shown by formula I [A- ring may have substituent(s); B-ring may be replaced by one oxo group; X is an active bond or (substituted) divalent hydrocarbon group; Y is a (substituted) nitrogen-contg. heterocycle; R is an electron-attracting group], e.g. 1,2- dihydro-1-(1-trifluoromethanesulfonylpiperidin-4-ylmethyl)-1,4,7b- triazacyclopento[cd]inden-2-one. The compound of formula I is obtained by reaction between a compound of formula II and a compound of formula III (E is a leaving group).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALCfJ0jnT28XRWcPb3DfAP9XPRUfAMCVYICPJ3CXUO8fT3U3D0c1HwdXXxdPb0c1cIDQaRIR6uCsGOvq48DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSTeK8DD0MDQwsjMxMTRmBg1AFR5Kik</recordid><startdate>19980707</startdate><enddate>19980707</enddate><creator>SHIBOUTA YUMIKO</creator><creator>KAWAMOTO TETSUJI</creator><creator>TAKATANI MUNEO</creator><scope>EVB</scope></search><sort><creationdate>19980707</creationdate><title>TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME</title><author>SHIBOUTA YUMIKO ; KAWAMOTO TETSUJI ; TAKATANI MUNEO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH10182644A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIBOUTA YUMIKO</creatorcontrib><creatorcontrib>KAWAMOTO TETSUJI</creatorcontrib><creatorcontrib>TAKATANI MUNEO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHIBOUTA YUMIKO</au><au>KAWAMOTO TETSUJI</au><au>TAKATANI MUNEO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME</title><date>1998-07-07</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-remedying effect, lipid reducing effect, etc. SOLUTION: This new tricyclic compound (salt) is shown by formula I [A- ring may have substituent(s); B-ring may be replaced by one oxo group; X is an active bond or (substituted) divalent hydrocarbon group; Y is a (substituted) nitrogen-contg. heterocycle; R is an electron-attracting group], e.g. 1,2- dihydro-1-(1-trifluoromethanesulfonylpiperidin-4-ylmethyl)-1,4,7b- triazacyclopento[cd]inden-2-one. The compound of formula I is obtained by reaction between a compound of formula II and a compound of formula III (E is a leaving group).</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME
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