TRICYCLIC COMPOUND, ITS PRODUCTION AND MEDICING USING THE SAME

PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-rem...

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Hauptverfasser: SHIBOUTA YUMIKO, KAWAMOTO TETSUJI, TAKATANI MUNEO
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To obtain a new tricyclic compound free from any substituent on the imidazole ring of the tricyclic fundamental skeleton, having a nitrogen-contg. heterocycle in the side chain, low in toxicity, and excellent in platelet-derived growth factor-suppressive effect, nephropathy-remedying effect, lipid reducing effect, etc. SOLUTION: This new tricyclic compound (salt) is shown by formula I [A- ring may have substituent(s); B-ring may be replaced by one oxo group; X is an active bond or (substituted) divalent hydrocarbon group; Y is a (substituted) nitrogen-contg. heterocycle; R is an electron-attracting group], e.g. 1,2- dihydro-1-(1-trifluoromethanesulfonylpiperidin-4-ylmethyl)-1,4,7b- triazacyclopento[cd]inden-2-one. The compound of formula I is obtained by reaction between a compound of formula II and a compound of formula III (E is a leaving group).