OPTICALLY ACTIVE PIPERIDINE DERIVATIVE AND ITS PRODUCTION

OPTICALLY ACTIVE PIPERIDINE DERIVATIVE AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To produce a diasteremoer salt useful as an intermediate for syntheses of pharmaceuticals having antihistaminic and antiallergic activities by optically resolving a specific piperazine derivative by using L(+)-tartaric acid. SOLUTION: This diastereomer, which consists of (S)-(-...

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Bibliographische Detailangaben
Hauptverfasser: KITA JUNICHIRO, TAKAMURA SHINJI
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To produce a diasteremoer salt useful as an intermediate for syntheses of pharmaceuticals having antihistaminic and antiallergic activities by optically resolving a specific piperazine derivative by using L(+)-tartaric acid. SOLUTION: This diastereomer, which consists of (S)-(-)-4-[(4-chlorophenyl)(2- pyridyl)methoxyl]piperidine.L(+)-tartarate of formula I, is obtained by making a racemic modification of formula II react with L(+)-tartaric acid, and fractivonally crystallizing the formed salt. Furthermore, by treating this diastereomer slat with an alkali to decompose, (S)-(-)-4-[(4-chlorophenyl)(2- pyrizyl)methoxyl]piperidine can be obtained.