ANTI-INFLAMMATORY AND ANTICANCER AGENT WITH HYDRONAPHTHALENE DERIVATIVE AS ACTIVE INGREDIENT, AND NEW HYDRONAPHTHALENE DERIVATIVE

PROBLEM TO BE SOLVED: To obtain the subject new compound having an activity to inhibit production of O2 by human neutrophil, activity to inhibit growth of the mouse's lymphatic leukemia cell P388, and an anti-inflammatory and anticancer action. SOLUTION: This hydronaphthalene derivative is shown by formula I or II (R is OH, a lower akoxy or NR R ; R and R are each H or a C-C double bond chain; R , R and R are each H or a lower alkyl; R and R are each H, OH, a lower alkoxy or C-C double bond chain; R is H, OH or a lower alkoxy; R and R are each H or a lower alkyl), e.g. [2E,4E]-5-(5',6',7',8'- tetrahydro-1'-naphthyl)-2,4-pentadienoic acid. The compound shown by formula I is obtained from Penicillium citrinum SCRC-SA124 cultivated under an aerobic condition by organic solvent extraction or chromatographic separation of the cultivated bacterium or the supernatant of the medium. The compound shown by formula II is obtained by the chemical synthesis in which 5,6,7,8-tetrahydro-1- naphthyltrifluoromethanesulfonate is reacted with ethyl [2E,4E]-5- tributylstannyl-2,4-pentadienoate or the like.