MANUFACTURE OF AMINOALKYNES SUBSTITUTED WITH N-HYDOROXYALKYL BY USING HETEROGENEOUS CATALYST

PROBLEM TO BE SOLVED: To obtain the subject compound under low pressure by using a catalyst containing metal compounds of a first and a second subgroup elements and gaseous C2 H2 , etc., when carrying out the reaction of an alkyd with a 1-oxa-3- azaheterocycloalkane. SOLUTION: An N-hydroxyalkyl substituted aminoalkyne expressed by formula II is manufactured by reacting a mixture of a compound expressed by the formula R -C≡C-H(R is H, an alkyl, etc.) and a compound expressed by formula I (R , R are each H, an alkyl, etc.; A is a 2-5 alkylene) in the presence of a catalyst containing a metal compound of a first subgroup elements under a heterogeneous catalytic system. A suitable catalyst contains a complex of copper acetylide and Bi compound, for example, (BiO)2 CO3 , etc., the preferable catalyst contains about 40-70wt.% of Cu and about 0.1-10% of Bi. The reaction is carried out in a reactor such as a tubular reactor, etc., provided with a stirrer, generally at 0-200 deg.C, preferably at 20-120 deg.C, especially preferably at 40-120 deg.C.