THIAZOLE DERIVATIVE

PROBLEM TO BE SOLVED: To obtain a new thiazole derivative useful as an antiinflammatroy agent, antiallergic agent, cancer metastasis inhibitor, immunosuppressive agent, etc., having inhibitory activity against cell adhesion. SOLUTION: This thiazole derivative is shown by formula II R is H, a lower alkyl, OH, etc.; R and R are each H or a lower alkyl; A is a group of formula II [R to R are each H, a (substituted) lower alkyl, etc.; Y is O, S, etc.]; B is C(O)N(R ) (R is H or a lower alkyl), etc.; D is a (substituted) aryl, a (substituted) aromatic heterocyclic ring, etc.; (m) is 0 or 1} such as (E)- N- 4-[2-(3-indolyl)ethylamino)carbonyl]-2-thiazolyl}-3-(4-biphenyl)-2-pro penamide. The derivative B, C(O)N(R ) is obtained by condensing a compound of the formula, A-CO2 H with a compound of formula III (R is a lower alkyl) to give a compound of formula IV, hydrolyzing the compound and reacting the resultant substance with a compound of formula V.