INDOLYL-SUBSTITUTED PHENYLACETIC ACID DERIVATIVE
N-Alkyl-4-((Indolyl, benzimidazolyl or imidazo-pyridinyl)methyl)-phenylacetamide derivatives of formula (I) and their salts are new. D = benzimidazolyl or imidazo-pyridinyl group of formula (D1) or 1-indolyl group of formula (D2); T = CH or N; R6, R7, R10, R11 = H, CF3, halogen, alkyl or alkoxy; R5,...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | N-Alkyl-4-((Indolyl, benzimidazolyl or imidazo-pyridinyl)methyl)-phenylacetamide derivatives of formula (I) and their salts are new. D = benzimidazolyl or imidazo-pyridinyl group of formula (D1) or 1-indolyl group of formula (D2); T = CH or N; R6, R7, R10, R11 = H, CF3, halogen, alkyl or alkoxy; R5, R8, R9 = H, 3-6C cycloalkyl, phenyl, up to 6C alkoxycarbonyl or alkyl (optionally substituted by halogen); R5 may also be benzyl if T = N; E, L = H, halogen, CF3, OH, COOH, alkyl, alkoxy or up to 6C alkoxycarbonyl; R1 = 3-10C cycloalkyl, 1-10C alkyl or phenyl (optionally substituted by 1 or 2 of halogen, CN, OH, 1-4C alkyl and 1-4C alkoxy); R2 = H or 1-3C alkyl; R3 = H, 1-5C alkyl or 3-7C cycloalkyl; or phenyl or 5-7 membered heteroaryl (containing 1-3 of S, N and O), both optionally substituted by 1-3 of halogen, NO2, Ph, OH, alkyl and alkoxy; R4 = H, CH2OH or CH1OCOR12; R12 = H, 1-8C alkyl or phenyl (optionally substituted by 1-3 of halogen, OH, CN, 1-4C alkyl and 1-4C alkoxy); alkyl moieties have 1-6C unless specified otherwise. |
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