NEW ANTIBIOTIC POLYKETOMYCIN AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain the subject new antibiotic useful as antibacterial agent, an antitumor agent, etc., having antibacterial and antitumor activity against gram-positive and gram-negative bacteria including methicillin-resistant bacteria, by culturing a bacterium belonging to the genus S...

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Hauptverfasser:	TAKEUCHI TOMIO, MOMOSE ISAO, HAMADA MASA, OSANAWA HIROSHI, IINUMA HIRONOBU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain the subject new antibiotic useful as antibacterial agent, an antitumor agent, etc., having antibacterial and antitumor activity against gram-positive and gram-negative bacteria including methicillin-resistant bacteria, by culturing a bacterium belonging to the genus Streptomyces, capable of producing polyketomycin. SOLUTION: This new antibiotic polyketomycin (salt) is expressed by the formula, shows antibacterial and antitumor activity against grampositive and gram-negative bacteria including methicillin-resistant bacteria and is useful as an antibacterial agent and an antitumor agent. This antibiotic is obtained by inoculating a bacterium [e.g. Streptomyces sp. MK277-AF1 strain (FERM P-15,442)] capable of producing polyketomycin of the formula into a medium, subjecting the bacterium to rotary shaking culture at 30 deg.C for five days to give a culture solution of a seed mash, adding the culture solution a liquid medium, subjecting the bacterium to rotary shaking culture at 27 deg.C for 4 days and collecting the product from the culture product by extraction, etc.