BICYCLIC HETEROCYCLIC COMPOUND

N-Alkyl-4-((N-containing bicyclic heterocyclyl)methyl)-phenylacetamide derivatives of formula (I) and their salts are new. A = bicyclic N-heterocyclyl of formula e.g. (A1)-(A7); L, M = H, halogen, CF3, OH, COOH, 3-6C cycloalkyl, OH, phenyl, alkyl, alkoxy or up to 6C alkoxycarbonyl; Q = N or CH; T =...

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Hauptverfasser: DEIRUKU DENTSUAA, URURIHI MIYURAA, HIRUMAA BISHIYOFU, RUDEI GURIYUTSUTSUMAN, JIIKUFURIITO GORUTOMAN, SHIYUTEFUAN ROOMAA, SHIYUTEFUAN BOORUFUAIRU, RICHIYAADO KONNERU
Format: Patent
Sprache:eng
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Zusammenfassung:N-Alkyl-4-((N-containing bicyclic heterocyclyl)methyl)-phenylacetamide derivatives of formula (I) and their salts are new. A = bicyclic N-heterocyclyl of formula e.g. (A1)-(A7); L, M = H, halogen, CF3, OH, COOH, 3-6C cycloalkyl, OH, phenyl, alkyl, alkoxy or up to 6C alkoxycarbonyl; Q = N or CH; T = SO2, CO, O or S; V = O or S; R -R = H, alkyl, benzyl or phenyl (optionally substituted by halogen or alkyl); R = CF3, benzyl, optionally benzo-fused heterocyclyl (containing 1-3 of S, N and O; and optionally substituted by 1-3 of halogen, Ph, OH, 1-4C alkyl or 1-4C alkoxy) or -S(O)a-R ; a = 0-2; R = 1-8C alkyl or 2-8C alkenyl (both optionally substituted by up to 6C acyl, or by up to 10C aryl or aroyl (themselves optionally substituted by 1 or 2 of halogen, CF3 and up to 5C acyl)); or 6-10C aryl (optionally substituted by halogen, OH, CF3, 1-5C alkyl or 1-5C alkoxy); D, E = H, halogen, CF3, OH, COOH, alkyl, alkoxy or up to 6C alkoxycarbonyl; Z = O or S; R = 3-10C cycloalkyl, 1-10C alkyl or phenyl (optionally substituted by 1 or 2 of halogen, CN, OH, 1-4C alkyl or 1-4C alkoxy); R = H or 1-3C alkyl; R = H, 1-5C alkyl or 3-7C cycloalkyl; or phenyl or 5-7 membered heteroaryl (containing 1-3 of S, N and O), both optionally substituted by 1-3 of halogen, NO2, Ph, OH, alkyl or alkoxy; R = H, CH2OH or CH2OCOR ; R = H, 1-8C alkyl or phenyl (optionally substituted by 1-3 of halogen, OH, CN, 1-4C alkyl and 1-4C alkoxy); alkyl moieties have 1-6C unless specified otherwise.