METHOD FOR PRODUCING (-)-8 ALPHA, 13-EPOXY-14,15,16-TRINORLABUDANE

PURPOSE: To quantitatively obtain the (-)-8α, 13-epoxy-14,15,16-trinorlabudane having a wood-like or amber-like perfume characteristics and useful as a compounding perfume raw material for cosmetics or foods in a high yield and in a high purity in simple processes without accompanying by-products. C...

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Bibliographische Detailangaben
Hauptverfasser:	KAWANOBE TSUNEO, TAKAZAWA OSAMU
Format:	Patent
Sprache:	eng
Schlagworte:	ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES APPARATUS THEREFOR CANDLES CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DETERGENTS ESSENTIAL OILS FATTY ACIDS THEREFROM GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PERFUMES PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRODUCING (PRESSING, EXTRACTION), REFINING AND PRESERVINGFATS, FATTY SUBSTANCES (e.g. LANOLIN), FATTY OILS AND WAXES,INCLUDING EXTRACTION FROM WASTE MATERIALS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE: To quantitatively obtain the (-)-8α, 13-epoxy-14,15,16-trinorlabudane having a wood-like or amber-like perfume characteristics and useful as a compounding perfume raw material for cosmetics or foods in a high yield and in a high purity in simple processes without accompanying by-products. CONSTITUTION: (-)-8α, 13-dihydroxy-14,15,16-trinorlabudane of formula I is subjected to a catalytic cyclization reaction in the presence of a zinc dihalide (e.g. zinc dichloride) as a dehydrative cyclization agent in an organic solvent such as dichloromethane or carbon tetrachloride to obtain the (-)-8α, 13- epoxy-14,15,16-trinorlabudane of formula II. The reaction temperature and the reaction time are approximately 0-50 deg.C and approximately 1-5hr, respectively. The zinc dihalide is used in an amount of approximately 1-2 moles per mole of the compound of formula II.