STEROL COMPOUND

PURPOSE:To obtain a new sterol compound having excellent antineoplastic activity, useful as a medicine, etc., by chemical modification of aragusterols extracted and isolated from a sponge belonging to Xestospongia. CONSTITUTION:This new sterol compound of formula III having excellent antineoplastic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	YAMADA TAIJI, YOKOO CHIHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new sterol compound having excellent antineoplastic activity, useful as a medicine, etc., by chemical modification of aragusterols extracted and isolated from a sponge belonging to Xestospongia. CONSTITUTION:This new sterol compound of formula III having excellent antineoplastic activity and useful as a medicine, etc., is obtained by chemical modification of aragusterol A of formula I or aragusterol D of formula II each extracted and isolated from a sponge belonging to Xestospongia gathered at the coral reef in the sea near Iriomote Island, Okinawa prefecture, Japan. This compound is obtained by reducing the aragusterol A of formula I or the aragusterol D of formula II with sodium borohydride in an alcohol followed by oxidation in methylene chloride in the presence of disodium hydrogenphosphate and m-chloroperbenzoic acid.