FUSED PROTEIN HAVING ANTITHROMBOGENIC ACTIVITY AND ITS PRODUCTION

PURPOSE: To obtain a DNA for expressing a fused protein having an antithrombogenic activity and useful for antithrombogenic medicines, platelet function-testing medicines, etc., in a host cell by a genetic recombination technique. CONSTITUTION: A DNA obtained by combining the first DNA fragment codi...

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Hauptverfasser:	NISHIDA YUKIYO, FUJIMURA YOSHIHIRO, TANAKA AKIKO, ISHII KOICHI, KOBAYASHI MIKI, MIURA SHUJI, KITO MORIKAZU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE: To obtain a DNA for expressing a fused protein having an antithrombogenic activity and useful for antithrombogenic medicines, platelet function-testing medicines, etc., in a host cell by a genetic recombination technique. CONSTITUTION: A DNA obtained by combining the first DNA fragment coding for a peptide having at least a part of a site bound to a glucoprotein lb with the second DNA fragment coding for a highly stable protein such as a maltose- bound protein. The DNA can be recombined with an expression vector suitable for a host cell, and the host cell. transformed with the expression vector, etc., can be cultured to express and produce a von Willebrand's disease factor fragment (antithrombogenic activity fragment) in a fused protein state with the stable protein and in a state having a combination activity with the platelet glucoprotein Ib.