HYDROINDAN-4-OL DERIVATIVE AND ITS PRODUCTION

PURPOSE: To obtain a hydroindan-4-ol derivative which is useful as a synthetic intermediate for vitamin D derivatives as a medicine in high stereoselectivity. CONSTITUTION: This objective compound is represented by formula I [R and R are each H, OH-protecting group; R is H, a (substituted) alkyl, an...

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Bibliographische Detailangaben
Hauptverfasser:	SHIMIZU NORIO, YAMANASHI MASAHIRO, RI SHIGETOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PURPOSE: To obtain a hydroindan-4-ol derivative which is useful as a synthetic intermediate for vitamin D derivatives as a medicine in high stereoselectivity. CONSTITUTION: This objective compound is represented by formula I [R and R are each H, OH-protecting group; R is H, a (substituted) alkyl, an alkenyl, an alkynyl, an aryl, an aralky], for example, octahydro-7a-methyl-1-(1-hydroxy-2- propyl)-1H-indene-4-ol. This compound is prepared by allowing a base such as lithium amide to react with an acetic ester derivative of formula II (R is identical to R ) in a solvent such as diethyl ether and allowing the product of enolate to act on 3-(4-hydroxyhydroindan)butanal derivative of formula III (R is identical to R ), when necessary, followed by OH protection or deprotection.