PRODUCTION OF 2'-DEOXY-5-TRIFLUOROMETHYL-BETA-URIDINE DERIVATIVE

PURPOSE:To obtain the subject derivative useful as an antitumor agent and an antiviral agent in high beta-selectivity and in a high yield by reacting specific compounds with each other in the presence of a copper compound as a catalyst and in the presence of fluoride ions in a specific solvent. CONS...

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Hauptverfasser:	KAWAUCHI KEIYA, FUKAZAWA NOBUYUKI, ISHIBASHI DAIKI
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SUGARS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain the subject derivative useful as an antitumor agent and an antiviral agent in high beta-selectivity and in a high yield by reacting specific compounds with each other in the presence of a copper compound as a catalyst and in the presence of fluoride ions in a specific solvent. CONSTITUTION:5-Trifluoromethyl-2,4-bis(trimethylsilyloxy)pyrimidine of formula I is reacted with a 2-deoxy-alpha-D-erythro-pentofuranosyl chloride derivative of formula II (X is halogen; X , X are H, halogen) in the presence of fluoride ions and in the presence of a copper compound such as cupric chloride or cupric fluoride as a catalyst in chloroform solvent to afford the objective compound of formula III, namely 1-(2'-deoxy-beta-D-erythro-pentofuranosyl)-5- trifluoromethyluracil derivative.