AZABICYCLOHEPTANE DERIVATIVE

PURPOSE:To obtain a new azacycloheptane derivative, not having narcotic properties like habit forming and indulgence, while keeping a sharp potency of morphine, useful as a non opioid analgesic with a clinically high safety and usefulness. CONSTITUTION:A compound of formula (wherein, R is H, a lower...

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Bibliographische Detailangaben
Hauptverfasser:	MACHIDA YOSHIMASA, KIMURA TEIJI, SENAGA MASAHIRO, AKASAKA KOZO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new azacycloheptane derivative, not having narcotic properties like habit forming and indulgence, while keeping a sharp potency of morphine, useful as a non opioid analgesic with a clinically high safety and usefulness. CONSTITUTION:A compound of formula (wherein, R is H, a lower alkyl, a lower alkoxy; Y is NH, CH2, O S; Z is either non substituted or substituted phenyl, pyridyl, N-oxypyridyl, pyrazyl, N-oxypyrazyl, pyrimidyl, N-oxypyrimidyl, pyridazyl, N-oxypyridazyl, quinolyl, N-oxyquinolyl, isoquinolyl, N-oxyisoquinolyl, indolyl, N-oxy -indolyl, furyl, tetrahydrofuryl, pyranyl, tetrahydropyranyl, thienyl, tetrahydrothienyl; n is 0-5; except that Z is 6-chloro-3- -pyridyl), e.g. exo-2-(6-bromo-3-pyridyl)-7- -azabicyclo[2.2.1]heptane.