OPTICALLY ACTIVE PHENOLIC DERIVATIVE AND PRODUCTION THEREOF

PURPOSE:To obtain an optically active phenolic derivative by reacting a phenolic compound with an optically active secondary carbinol compound in the presence of a tri-substituted phosphine and a diazodicarboxylate or a diazodicarboxamide. CONSTITUTION:This method for producing an optically active t...

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Bibliographische Detailangaben
Hauptverfasser:	SHIRAISHI MITSURU, FUKUMOTO MASAJI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL METHODS OF ORGANIC CHEMISTRY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain an optically active phenolic derivative by reacting a phenolic compound with an optically active secondary carbinol compound in the presence of a tri-substituted phosphine and a diazodicarboxylate or a diazodicarboxamide. CONSTITUTION:This method for producing an optically active tri-substituted methane compound expressed by formula III (R to R are each H or groups without participating in the reaction or the adjacent two are mutually bound to form a ring together with C; Q is an aromatic ring; R is a group without participating in the reaction; * denotes asymmetric C) is to react a phenolic compound, expressed by formula I and unsubstituted at the o- and/or the p- position with an optically active secondary carbinol compound, expressed by formula II and having an aromatic group at the alpha-position in the presence of a tri-substituted phosphine and a diazodicarboxylate or a diazodicarboxamide in an inert solvent (e.g. 1,2-dichloroethane) at -30 to +70 deg.C. The subject compound is useful as a medicine and a synthetic intermediate therefor and has treating and preventing actions on cerebropathy, cardiopathy, nephropathy and diseases in the pulmonary circulatory and respiratory systems, allergy, inflammation, etc.