THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS

PURPOSE:To provide a therapeutic agent and/or preventive agent esp. for atherosclerosis, containing, as the active ingredient, a thiazolidine derivative having activity to suppress oxidation/peroxidation of low-density lipoproteins. CONSTITUTION:The therapeutic agent and/or preventive agent for arte...

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Hauptverfasser:	IWAOKA SADAKI, TABATA FUMIKO, SAKU KEIJIROU, KOGA TEIICHIRO, YOSHIOKA TAKAO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	IWAOKA SADAKI TABATA FUMIKO SAKU KEIJIROU KOGA TEIICHIRO YOSHIOKA TAKAO
description	PURPOSE:To provide a therapeutic agent and/or preventive agent esp. for atherosclerosis, containing, as the active ingredient, a thiazolidine derivative having activity to suppress oxidation/peroxidation of low-density lipoproteins. CONSTITUTION:The therapeutic agent and/or preventive agent for arteriosclerosis containing as the active ingredient, a compound of the formula [R , R , R and R are each H or lower alkyl; R is H, an aliphatic acyl, (substituted) aromatic acyl or lower alkoxycarbonyl) or a pharmacologically permissible salt thereof, e.g. 5-[4-(6-hydroxy-2,5,7,8-tetramethylcoumarone-2-methoxy)benzyl] thiazolidine-2,4-dione. This compound can be administered orally or parenterally, its dose being normally 50-5000mg a day per adult.
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CONSTITUTION:The therapeutic agent and/or preventive agent for arteriosclerosis containing as the active ingredient, a compound of the formula [R , R , R and R are each H or lower alkyl; R is H, an aliphatic acyl, (substituted) aromatic acyl or lower alkoxycarbonyl) or a pharmacologically permissible salt thereof, e.g. 5-[4-(6-hydroxy-2,5,7,8-tetramethylcoumarone-2-methoxy)benzyl] thiazolidine-2,4-dione. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS
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