NEW (SUBSTITUTED) PHENYLIMIDAZOLIDINES, THEIR PRODUCTION, USE OF THEM AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The subject of the invention is the products of formula (I): in which: R1 and R2, which are identical or different, represent cyano, nitro, halogen, trifluoromethyl or free, esterified or salified carboxyl, the -A-B- group is chosen from the radicals in which X represents oxygen or sulphur and R3 is...

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Hauptverfasser: FURANSOWA GUUBE, JIYANJIYORUJIYU TOUUCHI, ANDORE KUROOSUNE
Format: Patent
Sprache:eng
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Zusammenfassung:The subject of the invention is the products of formula (I): in which: R1 and R2, which are identical or different, represent cyano, nitro, halogen, trifluoromethyl or free, esterified or salified carboxyl, the -A-B- group is chosen from the radicals in which X represents oxygen or sulphur and R3 is chosen from: - hydrogen - alkyl, alkenyl, alkynyl, aryl or arylalkyl, these radicals optionally being substituted; Y represents oxygen or sulphur or NH, R4 and R5, which are identical or different, represent hydrogen or optionally substituted alkyl or R4 and R5 form a cycloalkyl, with the exception of the products in which: R4 and R5 simultaneously represent a methyl radical, those in which one of R4 or R5 represents a methyl radical and the other a hydroxy-methyl radical, Y represents OH or =NH and -A-B- represents R1 represents 4-NO2 and R2 represents 3-CF3, their preparation and their application as medicaments, especially antiadrogens.