SPERGUALIN ANALOG AND ITS USE

PURPOSE:To obtain a new compound having low toxicity, chemical stability and excellent immunosuppressive action. CONSTITUTION:A compound of the formula GU-X1-(CH2)a-CONH-X2- CONH-(CH2)4-NH-(CH2)3-NH-Y [Gu is guanidino; X1 is (CH2)5 or phenylene; (a) is 4-13; (X2 is (CH2)0-2-CH(R00)0-2; R00 is H, OH,...

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Bibliographische Detailangaben
Hauptverfasser:	TOMIYOSHI TSUGIO, KOBAYASHI FUMIKO, NEMOTO KYUICHI, ITO JUNPEI, TAKESAKO KAZUTADA
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new compound having low toxicity, chemical stability and excellent immunosuppressive action. CONSTITUTION:A compound of the formula GU-X1-(CH2)a-CONH-X2- CONH-(CH2)4-NH-(CH2)3-NH-Y [Gu is guanidino; X1 is (CH2)5 or phenylene; (a) is 4-13; (X2 is (CH2)0-2-CH(R00)0-2; R00 is H, OH, OCH3 or CH2OH; Y is H or a residue after removal of OH from carboxyl of an amino acid or a peptide] or its salt such as 10-{N-(11-guanidinoundecanoyl)-r-amino-beta- hydroxybutanoyl}-1,5,10-triazadecane. The compound is obtained by removing a protecting group of a compound of the formula Gu-X1-(CH2)a-CONH-X2- CONH-(CH2)4-NR1-(CH2)3-NH-R2-R2 by reduction, acidolysis, hydrolysis, etc. The compound is useful for suppressing rejection in organ transplantation and skin graft and treating autoimmune diseases such as multiple sclerosis, hemolytic anemia, etc.