NEW CEPHALOSPORIN ANTIBIOTIC AND ITS PRODUCTION

Novel cephalosporin compounds of formula(I): wherein: R is a hydrogen or an amino protecting group; R and R are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group; R and R are, independently, a hydrogen or a carboxyl protecting group; X and Y ar...

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Hauptverfasser: JIYO YOSHIKAGE, HAYASHI SHIYOUSAN, KIN YOUCHIYUU, KIN SANSHIYOKU, U EIBIN, YANA TOKUHIRO, RI TAIKI, YO ZAIKOU, GO KEISHIYOU, KIN SEIHO, DEN ZAIKUN, HOU SANSHIYOKU
Format: Patent
Sprache:eng
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Zusammenfassung:Novel cephalosporin compounds of formula(I): wherein: R is a hydrogen or an amino protecting group; R and R are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group; R and R are, independently, a hydrogen or a carboxyl protecting group; X and Y are a nitrogen and a carbon atom, respectively, or a carbon and a nitrogen atom, respectively; R and R are, independently, a hydrogen or an amino, substituted amino, hydroxy, alkoxy, C1-4 alkyl, carboxyl or alkoxy carbonyl group, or jointly form a C3-7 cycloalkyl group together with the carbon to which they are attached, when X and Y are a nitrogen and a carbon, respectively, or R is a hydrogen or an amino group when X and Y are a carbon and a nitrogen, respectively; and Q is =CH- or =N-, or pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof, and isomers thereof possess potent and broad antibacterial activities.