NEW SESQUITERPENE DERIVATIVE

PURPOSE:To obtain a new compound having excellent retrovirus protease inhibiting action and useful as an anti-human immunodeficiency virus agent, etc. CONSTITUTION:A compound of formula I (R is hydroxymethyl and R is OH, or R is hydroxymethyl or formyl and R is H), e.g. the compound of formula II ha...

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Bibliographische Detailangaben
Hauptverfasser:	MIZUNO SUKETOSHI, OKAMOTO ROKURO, SHIBAMOTO NORIO, WATANABE YOSHIO, KUMAMOTO TOSHIHIKO, KOJIMA IKUO, AKAGAWA HISAYOSHI, DOBASHI KAZUYUKI, KOMINATO KAICHIRO, NISHIDA HIROSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new compound having excellent retrovirus protease inhibiting action and useful as an anti-human immunodeficiency virus agent, etc. CONSTITUTION:A compound of formula I (R is hydroxymethyl and R is OH, or R is hydroxymethyl or formyl and R is H), e.g. the compound of formula II having the following properties. Color and form, light yellow powder; melting point, slowly decomposing at 180 deg.C without exhibiting a definite melting point; molecular formula, C23H30O5; color reactions, positive to Gibbs reaction and 2,4-dinitrophenylhydrazine reagent; solubility, soluble in methanol, acetone, etc., and insoluble in water and n-hexane; classification by basic, neutral and acidic, acidic. This compound can be prepared by culturing a microorganism belonging to the genus Stachybotrys and capable of producing the compound of formula I [e.g. Stachybotrys sp. Mer-NF5O03 (FERM P-12344)] preferably under aerobic condition at 28 deg.C for usually 2-10 days and separating and purifying the compound from the cultured product.