HUMAN MONOCLONAL ANTIBODY

PURPOSE:To provide a human monoclonal antibody reactive on carcinoembryonic antigen(CEA), useful for diagnosis and therapy of cancer and low in antigenicity against human. CONSTITUTION:A human monoclonal antibody specifically recognizes the sugar chain part in CEA. In this antibody, the immunoglobul...

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Bibliographische Detailangaben
Hauptverfasser:	TSUKASAKI KATSUMI, KURODA KAZUHIKO, MOCHIZUKI KATSUMI, HASHIZUME SHUICHI, KATO MASATOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To provide a human monoclonal antibody reactive on carcinoembryonic antigen(CEA), useful for diagnosis and therapy of cancer and low in antigenicity against human. CONSTITUTION:A human monoclonal antibody specifically recognizes the sugar chain part in CEA. In this antibody, the immunoglobulin class belongs to IgG1 and the light chain is K chain. This human monoclonal antibody can be obtained by establishing anti-CEA antibody-producing human lymphocyte and culturing it. The established lymphocyte can be obtained by infecting the lymphocyte with EB virus so as to establish it, by fusing another established cell strain to the lymphocyte to form a hybridoma or by combining these two methods. The hybridoma capable of producing the human monoclonal antibody is preferably hybridoma strain BSRF-S-97 (FERM P-13920). This antibody can be applied, e.g. to an imaging agent for examining the position of a tumor of a cancer patient or a missile therapy for curing cancer by using it bonded to an antitumor substance.