CARCINOSTATIC AGENT

PURPOSE:To obtain a carcinostatic agent event having excellent activity in vivo and in vitro by using a complex of an anti-CEA human-type monoclonal antibody and a cytotoxic substance as an active component. CONSTITUTION:This carcinostatic contains, as an active component, a complex (immunotoxin) of...

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Bibliographische Detailangaben
Hauptverfasser:	TSUKASAKI KATSUMI, KURODA KAZUHIKO, MOCHIZUKI KATSUMI, HASHIZUME SHUICHI, KATO MASATOSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a carcinostatic agent event having excellent activity in vivo and in vitro by using a complex of an anti-CEA human-type monoclonal antibody and a cytotoxic substance as an active component. CONSTITUTION:This carcinostatic contains, as an active component, a complex (immunotoxin) of (A) an anti-CEA human-type monoclonal antibody S-97 produced by a hybridoma strain BSRF-S-97 and (B) a cytotoxic substance consisting of at least one kind of substances selected from cytotoxin (e.g pseudomonas exotoxin), a chemotherapeutic agent and a radioactive substance. The monoclonal antibody to CEA (carcinoembryonic antigen) is useful for the synthesis of an in vivo diagnostic or therapeutic agent for CEA-producing cancer such as digestive tract cancer and pulmonary cancer. Especially, an immunotoxin having CEA-producing cancer as the target has cytotoxic activity specific to CEA-producing gastric cancer cell strain and exhibits strong anticancer effect against the CEA-producing gastric cancer strain obtained by transplanting the immunotoxin to a nude mouse. The anti-CEA human-type monoclonal antibody is produced by establishing and culturing anti-CEA antibody-producing human.