IMIDAZOLE DERIVATIVE

PURPOSE:To provide the novel compound having an angiotensin II receptor- antagonizing action and using for therapy of hypertension, congestive heat failure, renal failure, glaucoma, etc. CONSTITUTION:A compound of formula I [R , R are H, halogen, lover alkyl, lower alkoxy; X is -CO2R (R is H, lower...

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Bibliographische Detailangaben
Hauptverfasser:	MACHII DAISUKE, SUZUKI KOJI, FUJIWARA SHIGEKI, FURUTA SHIHO, TAKAI HARUKI, OCHIFUJI NAGISA, ONO TETSUJI, YAMADA KOJI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PURPOSE:To provide the novel compound having an angiotensin II receptor- antagonizing action and using for therapy of hypertension, congestive heat failure, renal failure, glaucoma, etc. CONSTITUTION:A compound of formula I [R , R are H, halogen, lover alkyl, lower alkoxy; X is -CO2R (R is H, lower alkyl), -CN, etc.;-YZ is -CO-NR (R is H, lower alkyl), -CH=CH-, -CH2-CH2-, etc.; R is lover alkyl, cycloalkyl; R , R are H, halogen, etc.], e.g. 2-ethyl-3-[4-(2-methoxycarbonylnaphtho-1-yl) benzyl]-5,7-dimethyl-(3H)-imidazo[4,5-b]pyridine. The compound of formula I is obtained by reacting a compound of formula II (V is Cl, Br, I) with a compound of formula III in the presence of a base (e.g. sodium methoxide) in a solvent (e.g. methanol) at room temperature to 100 deg.C for 1-72hr.