HYDROXAMIC ACID DERIVATIVE

The invention provides hydroxamic acid derivatives of the formula wherein R represents a 5- or 6-membered N-heterocyclic ring, R and R each represent lower alkyl or NR R represents a saturated 5-, 6- or 7-membered heterocyclic ring, R , R , R and R each represent hydrogen or methyl, provided that at...

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Bibliographische Detailangaben
Hauptverfasser:	POORU ANSONII BURAUN, MAIKERU JIYON BUROODOHAASUTO, JIEFURII ROOTON, UIRIAMU HENRII JIYONSON
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides hydroxamic acid derivatives of the formula wherein R represents a 5- or 6-membered N-heterocyclic ring, R and R each represent lower alkyl or NR R represents a saturated 5-, 6- or 7-membered heterocyclic ring, R , R , R and R each represent hydrogen or methyl, provided that at least two of these symbols represent hydrogen and n stands for 1-4, and their pharmaceutically acceptable salts, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis.