PRODUCTION OF 1-HALO-2,2-DIFLUORO-D-RIBOFURANOSYL DERIVATIVE RICH IN ALPHA-ANOMER

PRODUCTION OF 1-HALO-2,2-DIFLUORO-D-RIBOFURANOSYL DERIVATIVE RICH IN ALPHA-ANOMER

A stereoselective process for preparing an alpha-anomer enriched 1- alpha -halo-2-deoxy-2,2-difluoro-D-ribofuranosyl derivatives involving contacting a 3,5-hydroxy protected-2-deoxy-2,2-difluoro-D-ribofuranosyl-1- beta -sulfonate with a halide source in an inert solvent.

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Bibliographische Detailangaben
Hauptverfasser: TOOMASU EDOWAADO MEIBURII, TAASEN CHIYOU, CHIYAARUZU DEIBITSUDO JIYOONZU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:A stereoselective process for preparing an alpha-anomer enriched 1- alpha -halo-2-deoxy-2,2-difluoro-D-ribofuranosyl derivatives involving contacting a 3,5-hydroxy protected-2-deoxy-2,2-difluoro-D-ribofuranosyl-1- beta -sulfonate with a halide source in an inert solvent.