SUBSTITUTED 2,4-IMIDAZOLIDINEDIONE

SUBSTITUTED 2,4-IMIDAZOLIDINEDIONE

Substituted 2,4-imidazolidinediones of the general formula in which R is straight-chain or branched alkyl having up to 8 carbon atoms, R is cycloalkyl having 3 to 8 carbon atoms, or straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl, or a group of...

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Hauptverfasser: TOOMASU KUREMAA, JIIKUFURIITO TSUAISU, URURIHI MIYURAA, HIRUMAA BISHIYOFU, MATEIASU MIYURAA GURIIMAN, PEETAA FUAI, YOHANESUUPEETAA SHIYUTASHIYU, RUDORUFU HANKO, MARUTEIN BOIKU, SHIYUTANISURAFU KATSUDA, DEIRUKU DENTSUAA, BARUTAA HIYUPUSHIYU, YURUGEN DORETSUSERU, ANDOREASU KUNORU, SHIYUTEFUAN BOORUFUAIRU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Substituted 2,4-imidazolidinediones of the general formula in which R is straight-chain or branched alkyl having up to 8 carbon atoms, R is cycloalkyl having 3 to 8 carbon atoms, or straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl, or a group of the formula -CH2-CO2R , R is a radical of the formula are prepared either by reaction of alpha -aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclisation with isocyanate or by reaction of N-benzyl-substituted alpha -aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with alpha -aminocarboxylic acid derivatives and subsequent cyclisation with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.