THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE

PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formu...

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Hauptverfasser: OKUI YOSHIKAZU, OSHIMA HIROICHI, SOGAWA TAKESHI, UEYAMA TAMIO, OSUGI YUMI, HIRASE JOJI, NISHIGAITO TOSHINORI, MATSUMOTO KAZUO, MIZUNO YASUO, NISHINO MINORU
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creator OKUI YOSHIKAZU
OSHIMA HIROICHI
SOGAWA TAKESHI
UEYAMA TAMIO
OSUGI YUMI
HIRASE JOJI
NISHIGAITO TOSHINORI
MATSUMOTO KAZUO
MIZUNO YASUO
NISHINO MINORU
description PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formula I [X is O or S; Y is thiocarbonyl or methylene; R is H, a halogen, cyano, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylthio, an acyloxy, an acyl, NR R (R and R are each H, an acyl, an alkyl, an aryl, etc.), dihydropyridyl, CONR R (R and R are each H, an alkyl, an alkenyl, an aryl, etc.), an alkenyl which may be substituted or an alkoxycarbonyl; (n) is 1 or 2] or its pharmacologically permissible salt, e.g. 1,3-benzoxathiol-2-thione as the active component. Among the compounds of formula I, compounds of formula II [R and R are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R and R are not an acyl in the fame time] are new compounds.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE
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