THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE
PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formu...
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creator | OKUI YOSHIKAZU OSHIMA HIROICHI SOGAWA TAKESHI UEYAMA TAMIO OSUGI YUMI HIRASE JOJI NISHIGAITO TOSHINORI MATSUMOTO KAZUO MIZUNO YASUO NISHINO MINORU |
description | PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formula I [X is O or S; Y is thiocarbonyl or methylene; R is H, a halogen, cyano, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylthio, an acyloxy, an acyl, NR R (R and R are each H, an acyl, an alkyl, an aryl, etc.), dihydropyridyl, CONR R (R and R are each H, an alkyl, an alkenyl, an aryl, etc.), an alkenyl which may be substituted or an alkoxycarbonyl; (n) is 1 or 2] or its pharmacologically permissible salt, e.g. 1,3-benzoxathiol-2-thione as the active component. Among the compounds of formula I, compounds of formula II [R and R are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R and R are not an acyl in the fame time] are new compounds. |
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Among the compounds of formula I, compounds of formula II [R and R are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R and R are not an acyl in the fame time] are new compounds.</description><edition>5</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941021&DB=EPODOC&CC=JP&NR=H06293640A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19941021&DB=EPODOC&CC=JP&NR=H06293640A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OKUI YOSHIKAZU</creatorcontrib><creatorcontrib>OSHIMA HIROICHI</creatorcontrib><creatorcontrib>SOGAWA TAKESHI</creatorcontrib><creatorcontrib>UEYAMA TAMIO</creatorcontrib><creatorcontrib>OSUGI YUMI</creatorcontrib><creatorcontrib>HIRASE JOJI</creatorcontrib><creatorcontrib>NISHIGAITO TOSHINORI</creatorcontrib><creatorcontrib>MATSUMOTO KAZUO</creatorcontrib><creatorcontrib>MIZUNO YASUO</creatorcontrib><creatorcontrib>NISHINO MINORU</creatorcontrib><title>THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE</title><description>PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formula I [X is O or S; Y is thiocarbonyl or methylene; R is H, a halogen, cyano, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylthio, an acyloxy, an acyl, NR R (R and R are each H, an acyl, an alkyl, an aryl, etc.), dihydropyridyl, CONR R (R and R are each H, an alkyl, an alkenyl, an aryl, etc.), an alkenyl which may be substituted or an alkoxycarbonyl; (n) is 1 or 2] or its pharmacologically permissible salt, e.g. 1,3-benzoxathiol-2-thione as the active component. Among the compounds of formula I, compounds of formula II [R and R are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R and R are not an acyl in the fame time] are new compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAP8XANcgxwDQ3xdFZwdHf1C1Fw8w9S8HANcAzxD_YMVnD0c1Ew1DHWdXL1i_KPcAzx8PT3UXBxDfIMcwzxDHPlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxXgEeBmZGlsZmJgaOxsSoAQB6LSqC</recordid><startdate>19941021</startdate><enddate>19941021</enddate><creator>OKUI YOSHIKAZU</creator><creator>OSHIMA HIROICHI</creator><creator>SOGAWA TAKESHI</creator><creator>UEYAMA TAMIO</creator><creator>OSUGI YUMI</creator><creator>HIRASE JOJI</creator><creator>NISHIGAITO TOSHINORI</creator><creator>MATSUMOTO KAZUO</creator><creator>MIZUNO YASUO</creator><creator>NISHINO MINORU</creator><scope>EVB</scope></search><sort><creationdate>19941021</creationdate><title>THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE</title><author>OKUI YOSHIKAZU ; OSHIMA HIROICHI ; SOGAWA TAKESHI ; UEYAMA TAMIO ; OSUGI YUMI ; HIRASE JOJI ; NISHIGAITO TOSHINORI ; MATSUMOTO KAZUO ; MIZUNO YASUO ; NISHINO MINORU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH06293640A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OKUI YOSHIKAZU</creatorcontrib><creatorcontrib>OSHIMA HIROICHI</creatorcontrib><creatorcontrib>SOGAWA TAKESHI</creatorcontrib><creatorcontrib>UEYAMA TAMIO</creatorcontrib><creatorcontrib>OSUGI YUMI</creatorcontrib><creatorcontrib>HIRASE JOJI</creatorcontrib><creatorcontrib>NISHIGAITO TOSHINORI</creatorcontrib><creatorcontrib>MATSUMOTO KAZUO</creatorcontrib><creatorcontrib>MIZUNO YASUO</creatorcontrib><creatorcontrib>NISHINO MINORU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OKUI YOSHIKAZU</au><au>OSHIMA HIROICHI</au><au>SOGAWA TAKESHI</au><au>UEYAMA TAMIO</au><au>OSUGI YUMI</au><au>HIRASE JOJI</au><au>NISHIGAITO TOSHINORI</au><au>MATSUMOTO KAZUO</au><au>MIZUNO YASUO</au><au>NISHINO MINORU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE</title><date>1994-10-21</date><risdate>1994</risdate><abstract>PURPOSE:To obtain a therapeutic agent for hepatosis containing a 1,3- benzoxathiol derivative including new compounds as the active component, having an excellent improving effect on hepatopathy and excellent in stability. CONSTITUTION:A therapeutic agent for hepatosis containing a compound of formula I [X is O or S; Y is thiocarbonyl or methylene; R is H, a halogen, cyano, an alkyl which may be substituted, an alkoxy which may be substituted, an alkylthio, an acyloxy, an acyl, NR R (R and R are each H, an acyl, an alkyl, an aryl, etc.), dihydropyridyl, CONR R (R and R are each H, an alkyl, an alkenyl, an aryl, etc.), an alkenyl which may be substituted or an alkoxycarbonyl; (n) is 1 or 2] or its pharmacologically permissible salt, e.g. 1,3-benzoxathiol-2-thione as the active component. Among the compounds of formula I, compounds of formula II [R and R are each H, an acyl, an alkyl, an aryl, an arylalkyl, heteroarylalkyl or an (alkylthio) thiocarbonyl, provided that both R and R are not an acyl in the fame time] are new compounds.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | THERAPEUTIC AGENT FOR HEPATOSIS AND 1,3-BENZOXATHIOL DERIVATIVE |
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