ADIPOCYTE-FORMATION SUPPRESSING FACTOR DERIVATIVE

PURPOSE:To obtain a new single polypeptide having activities to suppress the conversion of a cell into adipocyte, to suppress the lipoprotein lipase(LPL) of adipocyte, to induce the generation of colony stimulating factor(CSF) from a preadipocyte, to promote the antibody formation of B cell, to prom...

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Bibliographische Detailangaben
Hauptverfasser:	ITO YASUHIRO, KAWASHIMA ICHIRO, OSUMI JUN, MIYADAI KENJI, TAKIGUCHI HIROSHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To obtain a new single polypeptide having activities to suppress the conversion of a cell into adipocyte, to suppress the lipoprotein lipase(LPL) of adipocyte, to induce the generation of colony stimulating factor(CSF) from a preadipocyte, to promote the antibody formation of B cell, to promote the formation of blood megakaryocyte colony, to promote the generation of platelet and/or to shorten the G0 phase of hemopoietic precursor cell, a DNA coding the above polypeptide, etc. CONSTITUTION:A polypeptide produced by gene manipulation technique, having AGIF activity, essentially free from other proteins originated from human and constituted of an amino acid sequence of amino acid numbers 2-178 to 10-178 in the amino acid sequence expressed by the sequence number 2 of the sequence table. A DNA coding for this peptide. The new polypeptide is expected to be useful as an agent for the treatment of hypocytosis such as thrombopenia, an immune enhancement agent and an agent for the prevention or treatment of morbid obesity.