SUBSTITUTED ACETAMIDE DERIVATIVE

PURPOSE:To obtain a new substituted acetamide derivative capable of expecting effectiveness as a medicine for treating and preventing hypercholesterolemia, hyperlipemia, arteriosclerosis and heart diseases, etc., incidental thereto. CONSTITUTION:A compound of formula I (R is substitutive aryl or substitutive aromatic heterocyclic group; n is 0-2; R and R are H or lower alkyl; R is 3-10C alkyl, alkenyl or alkanoyl; R to R are H or lower alkyl or R and R and/or R and R together form single bond; R and R are H or lower alkyl or R and R together form single bond; R and R are H or lower alkyl or R and R form cycloalkane together with binding C; E are H, lower alkyl or lower alkoxy) or its pharmaceutically permissible salt, e.g. (E)- N-[2-N'-pentyl[-(6,6-dimethyl-2-hepten-4-ynyl)amino]ethyl]-(1-naphthyl thio) acetamide. The compound is obtained by subjecting a carboxylic acid compound of formula II to condensation reaction with an amine compound of formula III.